Taxol Biosynthesis: An Update
نویسندگان
چکیده
منابع مشابه
Taxol biosynthesis: an update.
The novel diterpenoid taxol (paclitaxel) is now well-established as a potent chemotherapeutic agent. Total synthesis of the drug is not commercially feasible and, in the foreseeable future, the supply of taxol and its synthetically useful progenitors must rely on biological methods of production. The first three steps of taxol biosynthesis have been defined and the responsible enzymes described...
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Two full-length cDNAs (TCH1 and TCH2) were obtained from a cDNA library of Taxus chinensis mainly by the single specific-primer PCR (SSP-PCR) method. Compared with other reported enzymes from Taxus species, the deduced amino acid sequences of TCH1 and TCH2 exhibit significant homologies to hydroxylases that are involved in taxol biosynthesis. These findings imply that the two new genes are clos...
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ژورنال
عنوان ژورنال: Planta Medica
سال: 1997
ISSN: 0032-0943,1439-0221
DOI: 10.1055/s-2006-957684